Whether 5- (and the 12- or 15-) lipoxygenases participate in normal or mali
gnantly transformed hematopoietic cell proliferation and differentiation, o
r contribute to programmed or necrotic cell death has been difficult to dec
ide. Recent evidence concerning these questions is reviewed and some reason
s for these difficulties are considered. (C) 1998 Elsevier Science Ltd. All
rights reserved.