Synthesis and antimycobacterial activity of new amidoderivatives of ortho-, meta- and para-toluidine.

Citation
M. Biava et al., Synthesis and antimycobacterial activity of new amidoderivatives of ortho-, meta- and para-toluidine., MED CHEM RE, 8(9), 1998, pp. 523-541
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
MEDICINAL CHEMISTRY RESEARCH
ISSN journal
10542523 → ACNP
Volume
8
Issue
9
Year of publication
1998
Pages
523 - 541
Database
ISI
SICI code
1054-2523(1998)8:9<523:SAAAON>2.0.ZU;2-7
Abstract
Novel toluidine derivatives are described. Some of them showed an interesti ng in vitro activity against Mycobacterium tuberculosis, M. smegmatis, M. m arinum, M. gordonae and M, avium. An anomalous reaction between cinnamoyl c hloride and the o-, m- and pi(N-methylpiperazinomethyl)anilines has also be en observed.