Cognitive implications for H-3 and 5-HT3 receptor modulation of cortical cholinergic function: A parallel story

Evidence reviewed in this paper suggests that interactions of histamine wit h H-3 receptors decrease the cholinergic tone in the frontal cortex and the hippocampus. These interactions may be important in learning and memory Bo th H-3 and 5-HT3 receptors represent targets for pharmacological interventi on by exogenous compounds acting as antagonists. Thus, the use of compounds with such properties as either thioperamide (H-3 receptor antagonist) or o ndansetron (5-HT3 antagonist) may represent a potential therapy to correct rile deficits resulting from cholinergic hypofunction. (C) 1998 Prous Scien ce. All rights reserved.