GenBank

The GenBank (Registered Trademark symbol) sequence database incorporates DN A sequences from all available public sources, primarily through the direct submission of sequence data from individual laboratories and from large-sc ale sequencing projects. Most submitters use the Banklt (Web) or Sequin pro grams to format and send sequence data. Data exchange with the EMBL Data Li brary and the DNA Data Bank of Japan helps ensure comprehensive worldwide c overage. GenBank data is accessible through NCBI's integrated retrieval sys tem, Entrez, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome and protein structure information. ME DLINE (Registered Trademark symbol) abstracts from published articles descr ibing the sequences are included as an additional source of biological anno tation through the PubMed search system. Sequence similarity searching is o ffered through the BLAST series of database search programs. In addition to FTP, Email, and server/client versions of Entrez and BLAST, NCBI offers a wide range of World Wide Web retrieval and analysis services based on GenBa nk data. The GenBank database and related resources are freely accessible v ia the URL:http://www.ncbi.nlm.nih.gov.