The eukaryotic promoter database (EPD): recent developments

The Eukaryotic Promoter Database (EPD) is an annotated non-redundant collec tion of eukaryotic POL II promoters, for which the transcription start site has been determined experimentally Access to promoter sequences is provide d by pointers to positions in nucleotide sequence entries. The annotation p art of an entry includes description of the initiation site mapping data, c ross-references to other databases, and bibliographic references. EPD is st ructured in a way that facilitates dynamic extraction of biologically meani ngful promoter subsets for comparative sequence analysis. Recent efforts ha ve focused on exhaustive crossreferencing to the EMBL nucleotide sequence d atabase, and on the improvement of the WWW-based user interfaces and data r etrieval mechanisms. EPD can be accessed at http://www.epd.isb-sib.ch.