Growth factors are proteins that help regulate the inflammatory response an
d wound healing in tissues. After laryngotracheal surgery, proper wound hea
ling is important in maintaining the reconstructed airway. The application
of growth factor to the respiratory mucosa of the larynx and ifs effect on
wound healing within the airway have not been studied. This study was desig
ned to establish a model for the evaluation of wound healing after the appl
ication of growth factor to composite respiratory mucosa and cartilage surf
aces at the time of laryngotracheoplasty. Forty rabbits underwent anterior
cricoid cartilage split with or without the use of a cartilage graft. Plate
let-derived growth factor or a placebo substance was applied to the wound a
t the time of surgery. This study offers a model for studying wound healing
in the airway that is reproducible with limited morbidity.