Objectives. To demonstrate the association between orthostatic intolerance
and the chronic fatigue syndrome (CFS) in adolescents and to delineate the
form that orthostatic intolerance takes in these children.
Study Design. We investigated the heart rate and blood pressure (BP) respon
ses to head-up tilt (HUT) in 26 adolescents aged 11 to 19 years with CFS co
mpared with responses in adolescents referred for the evaluation of simple
faint and to responses in 13 normal healthy control children of similar age
.
Results. A total of 4/13 of the controls and 18/26 simple faint patients ex
perienced typical faints with an abrupt decrease in BP and heart rate assoc
iated with loss of consciousness. One CFS patient had a normal HUT. A total
of 25/26 CFS patients experienced severe orthostatic symptoms associated w
ith syncope in 7/25, orthostatic tachycardia with hypotension in 15/25, and
orthostatic tachycardia without significant hypotension in 3/25. Acrocyano
sis, cool extremities, and edema indicated venous pooling in 18/25. None of
the control or simple faint patients experienced comparable acral or tachy
cardic findings.
Conclusions. We conclude that chronic fatigue syndrome is highly related to
orthostatic intolerance in adolescents. The orthostatic intolerance of CFS
often has heart rate and BP responses similar to responses in the syndrome
of orthostatic tachycardia suggesting that a partial autonomic defect may
contribute to symptomatology in these patients.