Intractable diarrhea from cytomegalovirus enterocolitis in an immunocompetent infant

Infection with cytomegalovirrs (CMV) in infants can be congenital or perina tal. Infected infants may be asymptomatic or present with pneumonia, rash, hepatosplenomegaly, or encephalitis.(1) In the presence of an immunodeficie ncy, severe and sometimes fatal disease may occur. To our knowledge, CMV ha s not been identified previously as a cause of intractable diarrhea of infa ncy. We report the case of a 5-week-old immunocompetent infant with intract able diarrhea attributable to CMV-induced enterocolitis. Recognition of thi s infection and initiation of ganciclovir therapy was associated with a rap id improvement and resolution of the diarrhea.