Clozapine associated neutropenia and cytomegalovirus colitis

Both diarrhea and colitis associated with clozapine have been reported. We present a case of clozapine-associated neutropenia complicated by cytomegal ovirus colitis. The definitive diagnosis was suggested on biopsy which show ed eosinophilic intranuclear inclusions suggestive of cytomegalovirus infec tion, and confirmed on immunohistochemistry. Neutropenia or agranulocytosis in association with clozapine treatment may be complicated by colitis. In such cases, investigations for cytomegalovirus may be incicated.