Objective To evaluate the effectiveness and safety of induction of labor in
women with previous Cesarean delivery.
Method We induced labor in 98 women with a history of previous Cesarean del
ivery in whom termination of gestation was indicated. Oxytocin was given to
women with premature rupture of the membranes and to women with intact mem
branes plus a Bishop index of > 7. Prostaglandin E-2 (0.5 mg) was given int
racervically in one or two doses 24 h apart in women with intact membranes
and a Bishop index of less than or equal to 7; this was followed by oxytoci
n if labor had not begun 24 h after the second dose. The control group cons
isted of 128 women with previous Cesarean delivery in whom labor had begun.
Results There was no significant difference in the vaginal delivery rate be
tween women in whom labor was induced (61.2%) and control women (68.8%). In
dication for previous Cesarean section was the only variable significantly
associated with successful trial of labor (p < 0.05). None of the patients
had dehiscence of the scar or uterine rupture.
Conclusion Induction of labor with intracervical prostaglandin E-2 and oxyt
ocin alone or in combination in women with previous Cesarean delivery is a
safe procedure for the mother and fetus.