About the use of molecular workbenches and platforms in organic synthesis

The concept of molecular workbenches is introduced. These workbenches are r igid templates onto which the substrate is fixed covalently and is thus arr anged in a conformationally defined way. The workbench may be disconnectibl e (i.e, after the functionalization of the substrate it is removed by bond cleavage) or non-disconnectible. In this case the workbench is irreversibly incorporated into the target structure. This concept is illustrated by add itions to (E) olefins (disconnectible workbench) and a synthesis of dihydro codeinone (non-disconnectible workbench).