DENSITOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PHARMACEUTICAL DOSAGE FORMS

This paper describes a simple densitometric method for the determinati on of metroprolol tartrate in tablets and ampoules. After separation o n silica gel GF254 plates, using acetone-methanol-triethylamine as the mobile phase for the tablets and acetone-triethylamine for ampoules, the chromatographic zones corresponding to the spots of metoprolol wer e scanned. Quantitation was performed using a computer-controlled Cama g TLC scanner and applying five-point calibration with polynomial regr ession. The calibration function was established in the ranges 1-28 mu g for tablets and 1-9 mu g for ampoules. The results obtained are pre cise and reproducible, with recovery values of 99.1-99.4%.