DEVELOPMENT AND VALIDATION OF A GENERAL NONDIGESTIVE METHOD FOR THE DETERMINATION OF PALLADIUM IN BULK PHARMACEUTICAL CHEMICALS AND THEIR SYNTHETIC INTERMEDIATES BY GRAPHITE-FURNACE ATOMIC-ABSORPTION SPECTROSCOPY

Authors
WANG T WALDEN S EGAN R
Citation
T. Wang et al., DEVELOPMENT AND VALIDATION OF A GENERAL NONDIGESTIVE METHOD FOR THE DETERMINATION OF PALLADIUM IN BULK PHARMACEUTICAL CHEMICALS AND THEIR SYNTHETIC INTERMEDIATES BY GRAPHITE-FURNACE ATOMIC-ABSORPTION SPECTROSCOPY, Journal of pharmaceutical and biomedical analysis, 15(5), 1997, pp. 593-599
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
15
Issue
5
Year of publication
1997
Pages
593 - 599
Database
ISI
SICI code
0731-7085(1997)15:5<593:DAVOAG>2.0.ZU;2-B
Abstract
A simple, selective, sensitive, accurate and relatively inexpensive me thod for the determination of palladium in bulk pharmaceutical chemica ls (BPC) and their synthetic intermediates by graphite furnace atomic absorption spectroscopy has been developed and validated. Sample prepa ration by direct dissolution of sample in 70% nitric acid is simple an d effective without adverse effects. The limit of detection and the li mit of quantitation of the method were determined to be 0.7 ppm and 2 ppm respectively in BPC.