A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13

Authors
Kramer, JA Adams, MD Singh, GB Doggett, NA Krawetz, SA
Citation
Ja. Kramer et al., A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13, SOM CELL M, 24(2), 1998, pp. 131-133
Citations number
15
Categorie Soggetti
Molecular Biology & Genetics
Journal title
SOMATIC CELL AND MOLECULAR GENETICS
ISSN journal
07407750 → ACNP
Volume
24
Issue
2
Year of publication
1998
Pages
131 - 133
Database
ISI
SICI code
0740-7750(199803)24:2<131:AMARLT>2.0.ZU;2-#
Abstract
The MarFinder algorithm was applied to a newly sequenced segment of 16p13,1 3 abutting the 3' end of the human PRM1 --> PRM2 --> TNP2 locus. A candidat e region of matrix attached was identified. Subsequent biophysical analysis showed that this region was attached to the somatic nuclear matrix. Nucleo tide sequence analysis also revealed the presence of a CpG island. Data bas e queries showed that this region contained the SOCS-1 gene. Thus, the SOCS -1 gene is bounded by a somatic MAR and is just 3' of the spermatid-express ed PRM1 --> PRM2 --> TNP2 domain at position 16p13.13.