Hypertonic saline prevents early bacterial translocation in hemorrhagic shock

The most appropriate solution for volume replacement in hemorrhagic shock i s controversial; however, hypertonic saline (HTS) solutions have recently g ained widespread acceptance. In this study, various solutions were used to resuscitate rats in hemorrhagic shock, and their impact on the extent of ba cterial translocation was investigated, Rats were bled to a mean arterial b lood pressure of about 35 mmHg which was maintained for 30 min. They were t hen randomized into sh groups, Blood pressure was found to be regulated by blood + lactated Ringer's solution (LR) and HTS + LR, but no significant im provement was observed in the control and LR groups. Groups II (7.5% HTS 60 ml/kg LR) and IV (60 ml/kg LR + autologous blood) had a significantly be tter result than groups I (7.5% HTS), III (60 ml/kg LR), and IV (P < 0.05), among which no statistically different results were seen (P > 0.05), While no organisms mere isolated from the mesenteric lymph nodes in the sham gro up, the rates of positive ;culture were 12.5%, 12.5%, 50%, 62.5%, and 62.5% in groups I, II, III, and the control group, respectively. Escherichia col i was the most commonly isolated organism. HTS + LR was demonstrated to be effective for decreasing the rate of early bacterial translocation to mesen teric lymph nodes and also for restoring the mean arterial pressure.