A simple synthesis of phosphonoformamides

Authors
Ferguson, CG Thatcher, GRJ
Citation
Cg. Ferguson et Grj. Thatcher, A simple synthesis of phosphonoformamides, SYNLETT, (12), 1998, pp. 1325-1326
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
12
Year of publication
1998
Pages
1325 - 1326
Database
ISI
SICI code
0936-5214(199812):12<1325:ASSOP>2.0.ZU;2-N
Abstract
A novel route to C-amides of the antiviral drug Foscarnet via the PFA diest er 4 is described. The reaction with amines is facilitated by in situ intra molecular cyclization to form a more reactive intermediate.