Moenomycin A: The role of the methyl group in the moenuronamide unit and ageneral discussion of structure-activity relationships

Authors
El-Abadla, N Lampilas, M Hennig, L Findeisen, M Welzel, P Muller, D Markus, A van Heijenoort, J
Citation
N. El-abadla et al., Moenomycin A: The role of the methyl group in the moenuronamide unit and ageneral discussion of structure-activity relationships, TETRAHEDRON, 55(3), 1999, pp. 699-722
Citations number
53
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
3
Year of publication
1999
Pages
699 - 722
Database
ISI
SICI code
0040-4020(19990115)55:3<699:MATROT>2.0.ZU;2-T
Abstract
Two disaccharide analogues 1b and 17a of moenomycin A have been synthesized and their antibiotic and transglycosylase-inhibiting properties have been determined. The results permit for the first time to arrive at a general vi ew of the structural requirements in this class of compounds necessary to e licit antibiotic activity. (C) 1998 Elsevier Science Ltd. All rights reserv ed.