Retro-aldol cleavage of bafilomycin derivatives

Authors
Granberg, KL Edvinsson, KM Nilsson, K
Citation
Kl. Granberg et al., Retro-aldol cleavage of bafilomycin derivatives, TETRAHEDR L, 40(4), 1999, pp. 755-758
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
4
Year of publication
1999
Pages
755 - 758
Database
ISI
SICI code
0040-4039(19990122)40:4<755:RCOBD>2.0.ZU;2-J
Abstract
The intermediates 3 and 4, useful in the preparation of new biologically ac tive bafilomycin derivatives, were obtained via a thermal retro-aldol react ion in diphenyl ether. The starting materials 5 and 7 for the retro-aldol r eaction were synthesized in a few steps from bafilomycin C-1 (2) with or wi thout a protective group at 7-OH. (C) 1999 Elsevier Science Ltd. All rights reserved.