Cyclisation of histidine containing peptides in the solid-phase by anchoring the imidazole ring to trityl resins

Authors
Sabatino, G Chelli, M Mazzucco, S Ginanneschi, M Papini, AM
Citation
G. Sabatino et al., Cyclisation of histidine containing peptides in the solid-phase by anchoring the imidazole ring to trityl resins, TETRAHEDR L, 40(4), 1999, pp. 809-812
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
4
Year of publication
1999
Pages
809 - 812
Database
ISI
SICI code
0040-4039(19990122)40:4<809:COHCPI>2.0.ZU;2-3
Abstract
Head-to-tail histidine containing cyclopeptides can be efficiently synthesi sed by a three-dimensional orthogonal solid-phase strategy (Fmoc/tBu/allyl) via anchoring the imidazole ring to trityl-resins. Furthermore, Fmoc-His(T rt-(R))-OAl can be a useful starting support for the preparation of diketop iperazine combinatorial libraries. (C) 1999 Elsevier Science Ltd. All right s reserved.