Synthesis of novel C-2 symmetrical and enantiomerically pure thiepines

Authors
Hudson, A Orpen, AG Phetmung, H Wyatt, P
Citation
A. Hudson et al., Synthesis of novel C-2 symmetrical and enantiomerically pure thiepines, TETRAHEDR L, 40(4), 1999, pp. 813-816
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
4
Year of publication
1999
Pages
813 - 816
Database
ISI
SICI code
0040-4039(19990122)40:4<813:SONCSA>2.0.ZU;2-5
Abstract
Novel thiepines were synthesised using a Sharpless asymmetric dihydroxylati on reaction to introduce the two chiral centres and with ring closure achie ved by using sulfur diimidazole in conjunction with either a double ortho-l ithiation or a double bromine/lithium exchange. (C) 1999 Elsevier Science L td. All rights reserved.