U. Kazmaier et A. Krebs, A straightforward synthesis of protected isostatine from achiral precursors using the asymmetric chelate Claisen rearrangement, TETRAHEDR L, 40(3), 1999, pp. 479-482
Starting from achiral TFA-protected glycine crotyl ester (3) the interestin
g, suitable protected, enantiomerically pure beta-hydroxy-gamma-amino acid
isostatine (7) was synthesized in only four steps. The amino acid obtained
can directly be introduced into peptides. (C) 1998 Elsevier Science Ltd. Al
l rights reserved.