Second primary renal cell carcinomas following solid tumors. Four case reports and review of the literature

We report multiple malignancies in four patients with metachronous renal ad enocarcinomas. The group of patients includes two women treated for primary breast and ovarian cancer and two men with prostate and colon cancer respe ctively. The occurrence of renal cancer following these primary solid tumor s was not associated with previous treatments. The authors review the liter ature and discuss pathogenic mechanisms underlying renal cell carcinoma.