The purpose of this study was to assess medical residents' knowledge of sym
ptom criteria and subtypes of major depressive episode and their accuracy i
n diagnosing major depressive disorders and classifying episode severity an
d subtype according to criteria of the Diagnostic and Statistical Manual of
Mental Disorders, Fourth Edition. Thirty-five third-year internal medicine
residents completed a self-administered, written instrument containing 2 o
pen-ended questions and 21 hypothetical scenarios. The sensitivity for reco
gnizing major depressive disorder was 64%, and the specificity was 69%. The
sensitivity for classifying severity was 86% for mild, 66% for moderate, 7
1% for severe, and 66% for severe with psychosis. Misclassification of seve
rity was most commonly to a less severe class. For scenarios with a diagnos
able subtype of a major depressive disorder, the sensitivity for classifica
tion was 34% for atypical, 51% for catatonic, 74% for melancholic, 100% for
postpartum, and 94% for seasonal depression. When asked to enumerate the c
riteria symptoms for depression, 80% or more of the residents listed sad mo
od, loss of interest, weight change, and sleep disturbances; 14 to 21 (40%-
60%) listed thoughts of death and worthlessness; other criteria were listed
by 7 to 11 (20%-31%). When asked to list the episode subtypes, none was li
sted by more than 3 (9%) residents, although 13 (37%) residents volunteered
psychotic as a subtype. Residents frequently failed to recognize the prese
nce or absence of major depressive disorder and often misclassified episode
severity and subtype on scenarios. Few could spontaneously list the episod
e subtypes. Methods must be developed to improve the recognition and classi
fication of major depressive episodes to better direct treatment.