Carcinosarcoma and pseudosarcoma of the esophagus: Two names, one disease - Comprehensive review of the literature

In the present review we have collected 127 carcinosarcomas and 56 pseudosa rcomas of the esophagus from the literature. There were no significant diff erences in age, sex, symptoms, location, or stalk involvement between the t wo groups. Infiltrative lesions were observed in 7.5% and 4.0%, respectivel y. The rate of lymph node metastasis was 52.5% for carcinosarcoma and 45.0% for pseudosarcoma. The resectability was similar in the two groups, and th e recurrence rates were 38.0% and 45.5%, respectively. Although recent immu nohistochemical and electron microscopic studies suggested that carcinosarc oma and pseudosarcoma are a single pathologic entity of epithelial origin, no one has ever compared the clinical behavior of the two entities. Our stu dy showed that the two neoplasms have similar clinical and behavioral outco mes. These findings support, once more, the unifying theory; and we suggest that the definition of "polypoid spindle cell carcinoma of the esophagus" be adopted.