MOLECULAR-GENETIC NATURE OF THE WHITE MUT ATIONS INDUCED BY CHEMICAL-SUBSTANCES IN DROSOPHILA-MELANOGASTER

Authors
SHCHERBATA GR MAXYMIV DV
Citation
Gr. Shcherbata et Dv. Maxymiv, MOLECULAR-GENETIC NATURE OF THE WHITE MUT ATIONS INDUCED BY CHEMICAL-SUBSTANCES IN DROSOPHILA-MELANOGASTER, Genetika, 33(1), 1997, pp. 19-24
Citations number
17
Categorie Soggetti
Genetics & Heredity
Journal title
Genetika → ACNP
ISSN journal
00166758
Volume
33
Issue
1
Year of publication
1997
Pages
19 - 24
Database
ISI
SICI code
0016-6758(1997)33:1<19:MNOTWM>2.0.ZU;2-W
Abstract
Molecular genetic mechanisms of the white mutations induced by mitomyc in C, N-ethyl-N-nitrosourea, and ethidium bromide were studied. Genomi c DNA of the original strain and mutants obtained was tested by Southe rn blot hybridization. The presence of mobile genetic elements was sho wn to be characteristic of the white locus of the original strain. Mut ations of the white gene obtained mainly resulted from excision of DNA sequences involving mobile genetic elements and insertion of unidenti fied 5-6-kbp DNA fragments.