Aims. To assess the prevalence of inhalant use among urban American Indian
youth and to examine differences between inhalant users and non-users. Desi
gn. Baseline (TI) self-report questionnaires completed in 5th-6th grade and
at seven annual follow-up assessments (T2-T8). Settings. Seattle metropoli
tan area. Participants. Two hundred and twenty-four Indian youth. Measureme
nts. Youth-completed measures of substance use, ethnic self-identity, invol
vement in traditional Indian activities, family conflict, family history of
alcoholism, peer and sibling deviance, self-esteem, delinquency, aggressio
n, anxiety, depression, sensation seeking, conduct disorder and alcohol dep
endence. Findings. Lifetime inhalant use was reported by 12.3% of adolescen
ts. At TI, inhalant users had significantly lower perceived self-worth and
average annual household incomes and significantly greater density of famil
ial alcoholism and expression of aggressive and delinquent conduct than non
-users. Aggressive behavior was the most important TI predictor of inhalant
use. Lifetime conduct and alcohol dependence disorders were 3.3 and 2.6 ti
mes more prevalent among inhalant users than non-users at T5. Inhalant user
s had more extensive deviant peer networks, were more sensation-seeking, an
d evidenced lower perceived self-worth than non-users at T8. Conclusions. I
nhalant use was less prevalent in this particular sample of urban Indian ad
olescents than in most studies of reservation Indian youth. As with other s
tudies of inhalant abuse, aggressive and delinquent males of low SES and la
w-perceived self-worth with family histories of alcohol dependence, were at
highest risk for inhalant use.