Intravenous versus subcutaneous vitamin K-1 in reversing excessive oral anticoagulation

Our data suggest that compared with the subcutaneous route of administratio n, intravenous vitamin K-1 results in a more prompt reduction in the intern ational normalized ration. However, for most patients, subcutaneous vitamin K-1 is an effective and safe alternative when used in conjunction with mod ification of subsequent warfarin dosing, because virtually all patients ach ieved a safe level of anticoagulation within 72 hours with this route of ad ministration.