THERMODYNAMICS AND MECHANISM OF COMPLEXATION OF PEPTIDES WITH 18-CROWN-6 IN WATER

Taking into account the unusual crystalline structures of 18-crown-6/p eptides/water complexes, the links between their thermokinetic behavio ur and the structural peculiarities are discussed. It has been found t hat the peptide chain lengthening leads to an increase in the temperat ure and activation energy of decomposition. The thermodynamics of comp lexation between small peptides and 18-crown-6 in water has been studi ed as well. It is shown that the influence of the peptide lengthening and the presence of a methyl group in the peptide side chain on the bi nding constant can be used as a the basis for the separation of peptid e mixtures in solution.