SYNTHETIC HEMES AS MIMICS FOR HIGH-VALENT INTERMEDIATES IN HEMOPROTEIN CATALYZED OXIDATIONS - SYNTHESIS AND OXIDATION OF CYANO-5,10,15,20-TETRAPHENYLPORPHYRINATOIRON(III), A HEME WHICH CONTAINS STRONGLY ELECTRON-WITHDRAWING GROUPS IN THE BETA-PYRROLE POSITIONS

Authors
ATKINSON ST BRADY SP JAMES JP NOLAN KB
Citation
St. Atkinson et al., SYNTHETIC HEMES AS MIMICS FOR HIGH-VALENT INTERMEDIATES IN HEMOPROTEIN CATALYZED OXIDATIONS - SYNTHESIS AND OXIDATION OF CYANO-5,10,15,20-TETRAPHENYLPORPHYRINATOIRON(III), A HEME WHICH CONTAINS STRONGLY ELECTRON-WITHDRAWING GROUPS IN THE BETA-PYRROLE POSITIONS, Pure and applied chemistry, 67(7), 1995, pp. 1109-1116
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Pure and applied chemistry → ACNP
ISSN journal
00334545
Volume
67
Issue
7
Year of publication
1995
Pages
1109 - 1116
Database
ISI
SICI code
0033-4545(1995)67:7<1109:SHAMFH>2.0.ZU;2-K
Abstract
The haem yano-5,10,15,20-tetraphenylporphyrinato-iron(III), which cont ains strongly electron withdrawing groups in the beta-pyrrole position s, has been synthesised as a possible substrate for oxidations which m imic the formation of high valent haems in peroxidase and cytochrome p -450 catalysed reactions. The porphyrin was synthesised by reacting th e copper(II) complex of the corresponding tetrabromoporphyrin with CuC N in quinoline. Treatment of the haem with m-chloroperbenzoic acid gav e an oxidation product which is stable in solution at room temperature .