A branching non-linear autoregressive model for the transmission of the fragile X dynamic repeat mutation

Authors
Huggins, RM Loesch, DZ Sherman, SL
Citation
Rm. Huggins et al., A branching non-linear autoregressive model for the transmission of the fragile X dynamic repeat mutation, ANN HUM GEN, 62, 1998, pp. 337-347
Citations number
30
Categorie Soggetti
Molecular Biology & Genetics
Journal title
ANNALS OF HUMAN GENETICS
ISSN journal
00034800 → ACNP
Volume
62
Year of publication
1998
Part
4
Pages
337 - 347
Database
ISI
SICI code
0003-4800(199807)62:<337:ABNAMF>2.0.ZU;2-8
Abstract
A non-linear time series version of a model for the transmission of fragile X previously described in Ashley & Sherman (1995) is developed. The model retains the biological features of the Ashley/Sherman model but is easier t o generalize and in particular allows the inclusion of covariates such as h aplotype to model different paths and random effects to model family effect s. The model is fitted to data from Murray et al. (1997) and its properties are illustrated in a simulation study.