TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal
Ht. Liu et al., TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal, BIOC BIOP R, 254(1), 1999, pp. 203-210
Citations number
37
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Using the cDNA-representative differences analysis (cDNA-RDA) approach, we
identified a novel gene, TFAR19 (TF-1 cell apoptosis related gene-19), from
TF-1 cells undergoing apoptosis. The human TFAR19 encodes a protein which
shares significant homology to the corresponding proteins of species rangin
g from yeast to mice. TFAR19 exhibits a ubiquitous expression pattern and i
ts expression is upregulated in the tumor cells undergoing apoptosis. Overe
xpression of TFAR19 in tumor cells enhances apoptosis triggered by growth f
actor or serum deprivation. We propose that TFAR19 may play a general role
in the apoptotic process. (C) 1999 Academic Press.