Sn. Kim et al., Effect of dimethyl-4,4 '-dimethoxy-5,6,5 ',6 '-dimethylenedioxybiphenyl-2,2 '-dicarboxylate (DDB) on chemical-induced liver injury, BIOL PHAR B, 22(1), 1999, pp. 93-95
The effects of orally administered dimethyl-4,4'-dimethoxy-5,6,5',6'-dimeth
ylene-dioxybiphenyl-2,2'-dicarboxylate (DDB) on the hepatotoxicity induced
by carbon tetrachloride, acetaminophen or ethanol were investigated in rats
and mice. Either single or repeated DDB pretreatment (50 or 200 mg/kg) did
not alter the hepatotoxicity induced by carbon tetrachloride (0.2 or 1.0 m
l/kg, i.p.) in female rats as indicated by increases in the activity of ala
nine aminotransferase (ALT), aspartate aminotransferase (AST) and sorbitol
dehydrogenase (SDH) in serum. The hepatotoxicity of acetaminophen (350 mg/k
g, i.p.) was also unaffected in male mice pretreated with DDB (50 mg/kg/d)
for a week. However, DDB administration (50 mg/kg/d for 7 d) decreased the
hepatic fatty degeneration induced by repeated ethanol treatment (0.75 g/kg
, i.p., x2 times a day for a week) in rats as shown by the accumulation of
triglycerides and cholesterol in the liver. Malondialdehyde (MDA) formation
in liver homogenates was inhibited by DDB treatment. The significance of t
he action of DDB on alcoholic fatty liver generation in clinical settings i
s discussed.