M. Leboyer et al., Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives, BIOL PSYCHI, 45(2), 1999, pp. 158-163
Background: Whole blood serotonin (5-HT) and C-terminally directed beta-end
orphin protein immunoreactivity (C-ter-beta-EP-ir) are known to be elevated
in autistic subjects and might be possible markers of genetic liability to
autism. This study thus investigates the familial aggregation of 5-HT and
of C-ter-beta-EP-ir levels in first degree relatives of autistic probands.
Methods: In a sample of 62 autistic subjects and 122 of their first-degree
relatives, compared to age and sex-matched controls, we measured 5-HT by ra
dioenzymology and C-ter-beta-EP-ir by radioimmunoassay,
Results: We confirm the previously reported familiality of hyperserotoninem
ia in autism as mothers (51%), fathers (45%) and siblings (87%) have elevat
ed levels of 5-HT, and we reveal presence of elevated levels of C-ter-beta-
EP-ir in mothers (53%) of autistic subjects.
Conclusions: Familial aggregation of quantitative variables, such as concen
tration of neurotransmitters, within unaffected relative could serve as an
intermediate phenotype and might thus help the search of genetic susceptibi
lity factors in autism. (C) 1999 Society of Biological Psychiatry.