Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

Authors
Ribatti, D Vacca, A Nico, B Quondamatteo, F Ria, R Minischetti, M Marzullo, A Herken, R Roncali, L Dammacco, F
Citation
D. Ribatti et al., Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma, BR J CANC, 79(3-4), 1999, pp. 451-455
Citations number
43
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
79
Issue
3-4
Year of publication
1999
Pages
451 - 455
Database
ISI
SICI code
0007-0920(199902)79:3-4<451:BMAAMC>2.0.ZU;2-Q
Abstract
Immunohistochemical, cytochemical and ultrastructural data showing vivid an giogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM , and that MCs participate in its induction via angiogenic factors in their secretory granules.