E. Fujimori et al., Multielement determination of major-to-ultratrace elements in biological samples by analytical plasma spectrometry, BUNSEKI KAG, 48(1), 1999, pp. 57-67
The multielement determination of major-to-ultratrace elements in biologica
l samples by ICP-AES (inductively coupled plasma atomic emission spectromet
ry) and ICP-MS (inductively coupled plasma mass spectrometry) is reported.
Matrix effects, especially due to organic compounds contained at high conce
ntrations in biological samples, were examined in detail in terms of non-sp
ectral interference and polyatomic ion interference. It was found that the
interference of (ArC)-Ar-40-C-12 with Cr-52 could be corrected by the CF (c
orrection factor) method, which was estimated from the apparent ion counts
of Cr-52 and the emission intensity of C at 247.8 nm. The major-to-ultratra
ce elements in freeze-dried human urine standard reference material (NIST S
RM 2670; elevated) and human hair reference material (NIES CRM No. 13) were
determined using both ICP-AES and ICP-MS. Furthermore, rare earth elements
(REEs) in human blood serum (human blood serum reference material NIES CRM
No. 4 and personal human blood serum samples) were determined by ICP-MS af
ter acid digestion and chelating resin preconcentration. The REE distributi
on pattern of human blood serum showed some similarity to that of seawater.