Efficient site specific cleavage of RNA using a terpyridine-copper(II) complex joined to a 2 '-O-methyloligonucleotide by a non-flexible linker

Authors
Inoue, H Furukawa, T Shimizu, R Tamura, T Matsui, MN Ohtsuka, E
Citation
H. Inoue et al., Efficient site specific cleavage of RNA using a terpyridine-copper(II) complex joined to a 2 '-O-methyloligonucleotide by a non-flexible linker, CHEM COMMUN, (1), 1999, pp. 45-46
Citations number
14
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
1
Year of publication
1999
Pages
45 - 46
Database
ISI
SICI code
1359-7345(19990107):1<45:ESSCOR>2.0.ZU;2-P
Abstract
A terpyridine-Cu(II) complex conjugated to an antisense 2'-O-methyloligonuc leotide at the 5'-end cleaved RNA predominantly at the site opposite the 5' -end in moderate yield, but the cleavage yield increased by more than two-f old when a 2'-O-methyloligonucleotide was allowed to bind to the single-str anded region of the RNA-antisense complex.