Enantioselective hydrolysis of 1-butyryloxyalkylphosphonates by lipolytic microorganisms: Pseudomonas fluorescens and Penicillium citrinum

Authors
Skwarczynski, M Lejczak, B Kafarski, P
Citation
M. Skwarczynski et al., Enantioselective hydrolysis of 1-butyryloxyalkylphosphonates by lipolytic microorganisms: Pseudomonas fluorescens and Penicillium citrinum, CHIRALITY, 11(2), 1999, pp. 109-114
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
CHIRALITY
ISSN journal
08990042 → ACNP
Volume
11
Issue
2
Year of publication
1999
Pages
109 - 114
Database
ISI
SICI code
0899-0042(1999)11:2<109:EHO1BL>2.0.ZU;2-4
Abstract
A simple and efficient method was developed for the preparation of opticall y active 1-hydroxyalkylphosphonates. Diethyl 1-butyryloxyalkylphosphonates were hydrolysed by whole cell cultures of Pseudomonas fluorescens or Penici llium citrinum to the afford corresponding hydroxyphosphonates with moderat e to good yields and satisfactory optical purity. The substrate specificity of these two microorganisms is discussed in detail. (C) 1999 Wiley-Liss, I nc.