Changes in left ventricular diastolic function 6 months after nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy

Background-Nonsurgical septal reduction therapy (NSRT) decreases left ventr icular outflow tract (LVOT) gradient and improves symptoms in patients with hypertrophic obstructive cardiomyopathy (HOCM). NSRT effects on LV/left ve ntricular diastolic function are currently unknown. Methods and Results-HOCM patients (n=29) had Doppler echocardiography at ba seline and 6 months after NSRT to evaluate changes in LV volume, pre-A-wave pressure, early diastolic mitral annulus velocity (Ea) by tissue Doppler, and tau. At 6 months, a significant reduction in LVOT gradient (from 53.63/-15 to 6+/-5 mm Hg; P<0.001) was accompanied by improvement in exercise du ration (from 284+/-147 to 408+/-178 seconds; P=0.04) and New York Health As sociation class (from III to I; P<0.001). Pre-A pressure (18+/-6 to 13+/-5 mm Hg; P<0.01) and tau (62+/-8 to 51+/-8 ms; P<0.01) decreased, whereas Ea (5.8+/-1.8 to 8+/-1.8 cml/s; P<0.01) and LV end-diastolic volume (117+/-16 to 130+/-22 mL; P<0.01) increased. Conclusions-NSRT improves LV relaxation and compliance, which contributes t o the symptomatic relief seen at 6 months.