The understanding of arthritis and possible treatment options continues to
improve. This article discusses classification of articular cartilage degen
eration, osteochondral defects, osteotomy, and a variety of treatments. Dev
elopments in the study of growth factors, molecular biology, and gene thera
py make the future bright; it is contingent, however, on critical factors s
uch as controlled studies, accurate inclusion criteria, outcome measurement
, and long-term follow-up.