Synthesis and anticancer activity of new derivatives of podophyllotoxin

Authors
Cui, YJ Tian, XA
Citation
Yj. Cui et Xa. Tian, Synthesis and anticancer activity of new derivatives of podophyllotoxin, CURRENT SCI, 75(12), 1998, pp. 1383-1386
Citations number
9
Categorie Soggetti
Multidisciplinary,Multidisciplinary
Journal title
CURRENT SCIENCE
ISSN journal
00113891 → ACNP
Volume
75
Issue
12
Year of publication
1998
Pages
1383 - 1386
Database
ISI
SICI code
0011-3891(199812)75:12<1383:SAAAON>2.0.ZU;2-M
Abstract
Six new 4-alklyamino compounds 6.1-6.4, 7.1-7.3, derived from podophyllotox in have been synthesized and evaluated for their anticancer activity in vit ro. All analogues of podophyllotoxin showed inhibitory activity against L12 10 and K562 cells. Compounds 6.2, 6.3, 6.4, 7.1, 7.2 are as potent or more potent than VP-16 in their inhibition of L1210 cells, The inhibitory activi ties of all analogues against K562 cells are less potent than that of VP-16 .