Amitriptyline-induced erythema annulare centrifugum

A case of amitriptyline-induced superficial erythema annulare centrifugum ( EAC) is reported, Its singular characteristics are prominent epidermal mani festations, with clinical and histologic vesiculation, associated with vacu olar degeneration at the dermoepidermal junction; numerous arciform lesions , accompanied by diffuse erythema on rechallenge; quick change, more rapid than that usually described for EAC; and a short course, in contrast with t he usual chronic evolution of EAC, To our knowledge, this is the first repo rted case of EAC associated with amitriptyline intake.