Transition metal ion-catalyzed oxygen activation during pathogenic processes

Most pathological processes include the production of activated oxygen spec ies augmented or attenuated by transition metal ions catalyzing one electro n transitions. Inhalation of airborne particles, infections, ingestion of t oxins or liberation from endogenous stores represent biological pathways fo r the induction of pathogenic processes by these metal ions, In this short review basic reactions involving transition metal ions operating during oxi dative stress in certain diseases will be discussed. (C) 1999 Federation of European Biochemical Societies.