The use of clinical outcomes to evaluate the effectiveness of various pharm
aceutical and medical interventions has inspired the health care community
to develop innovative techniques to measure the impact of these interventio
ns, We describe the use of an electronic medical records system to conduct
and apply outcomes research on drugs used at an academic medical center, Th
e Medical ARchival System (MARS) at the University of Pittsburgh Medical Ce
nter (UPMC) Health System is a comprehensive clinical and financial data re
pository, A model program was developed that incorporated MARS, which was u
ltimately able to provide practical, timely information about how drugs are
actually used in routine clinical practice at UPMC, to determine whether i
ntended outcomes had been achieved, to identify undesirable outcomes, and t
o track financial information.