Polymorphism of noncoding regions of the mitochondrial genome in the indigenous population of southeastern Tuva Republic

Deletion-insertion polymorphism of the V region and restriction polymorphis m of D-loop for seven restriction enzymes-AspS9I (Cfr3I isoschizomere), Bam HI, Bme18I (AvaII), EcoRV, HaeIII, KpnI, and Kzo9I (Sau3AI)-in mitochondria l DNA (mt DNA) were studied in the indigenous population of southeastern Tu va Republic. The results were compared with the data on Russians, Mongols, Buryats, and Altaians. Tuvinians significantly differed from Mongols in the frequency of the 9-bp deletion of the V region (1.89 and 8.07%, respective ly). Additionally, significant differences between Tuvinians and samples of Mongols and Russians were obtained for frequencies of the AspS9I, HaeIII, and KpnI restriction sites. A comparison of the polymorphism of mitochondri al genome in individuals of different sexes and ages was performed in the s tudied sample.