A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34

Authors
Hadano, S Nichol, K Brinkman, RR Nasir, J Martindale, D Koop, BF Nicholson, DW Scherer, SW Ikeda, JE Hayden, MR
Citation
S. Hadano et al., A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34, GENOMICS, 55(1), 1999, pp. 106-112
Citations number
30
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENOMICS
ISSN journal
08887543 → ACNP
Volume
55
Issue
1
Year of publication
1999
Pages
106 - 112
Database
ISI
SICI code
0888-7543(19990101)55:1<106:AYACPM>2.0.ZU;2-S
Abstract
The autosomal recessive form of juvenile amyotrophic lateral sclerosis (ALS 2; RFALS Type 3) has previously been mapped to the 8-cM interval flanked by D2S115 and D2S155 on human chromosome 2q33-q34, We have established a yeas t artificial chromosome (YAC) contig spanning an approximately 8-Mb region of the ALS2 candidate region and mapped 52 transcribed DNA sequences includ ing 13 known genes and 39 expressed sequenced tags within this YAC contig, The establishment of a YAC contig and transcript map that spans the region containing the ALSB mutation is an essential step in the identification of the ALS2 gene. (C) 1999 Academic Press.