Kinetic and mechanistic studies on the oxidation of norfloxacin by chloramine-B and N-chlorobenzotriazole in acidic medium

The kinetics of oxidation of Norfloxacin [1-ethyl-6-fluoro-1,4-dihydro-4-ox o-7-(1-piperazinyl)-3-quinoline carboxylic acid] by chloramine-B and N-chlo robenzotriazole has been studied in aqueous acetic acid medium (25% v/v) in the presence of perchloric acid at 323 K. For both the oxidants, the react ion follows a first-order dependence on [oxidant], a fractional-order on [N orfloxacin], and an inverse- fractional order on [H+]. Dependence of reacti on rate on ionic strength, reaction product, dielectric constant, solvent i sotope, and temperature is studied. Kinetic parameters are evaluated. The r eaction products are identified. The proposed reaction mechanism and the de rived rate equation are consistent with the observed kinetic data. Formatio n and decomposition constants for substrate-oxidant complexes are evaluated . (C) 1999 John Wiley & Sons, Inc.