A. Cesano et al., Biodistribution of human MHC non-restricted TALL-104 killer cells in healthy and tumor bearing mice, INT J ONCOL, 14(2), 1999, pp. 245-251
The human cytotoxic T cell line TALL-104 displays potent anti-tumor effects
in animals with spontaneous and induced malignancies. We investigated the
biodistribution of TALL-104 cells in tumor bearing and healthy mice. In-111
-labeled TALL-104 cells, injected intravenously, localized primarily in the
lungs for the first 2 h, and redistributed to liver, spleen, and kidneys i
n the following 24 h both in immunodeficient and immunocompetent mice. TALL
-104 cells consistently accumulated in the tumor and at sites of metastases
. In animals injected with free In-111-oxine, most of the radioactivity rem
ained in the blood pool with no significant organ accumulation. These data
support the tumor homing properties of TALL-104 cells, information which is
crucial to their therapeutic efficacy in forthcoming clinical trials.