Spectrophotometric determination of pK(a) of nimesulide

Authors
Singh, S Sharda, N Mahajan, L
Citation
S. Singh et al., Spectrophotometric determination of pK(a) of nimesulide, INT J PHARM, 176(2), 1999, pp. 261-264
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN journal
03785173 → ACNP
Volume
176
Issue
2
Year of publication
1999
Pages
261 - 264
Database
ISI
SICI code
0378-5173(19990101)176:2<261:SDOPON>2.0.ZU;2-L
Abstract
The note reports on the determination of pK(a) of nimesulide, a potent anti -inflammatory agent, by a spectrophotometric method. The ruggedness of the result was validated by determination by different persons on different day s and on different spectrophotometers employing different drug concentratio ns. Compared to the literature reports of pK(a) values of 5.90, 6.46, 6.50 and 6.80, the value calculated in the present study is 6.56 +/- 0.01. (C) 1 999 Elsevier Science B.V. All rights reserved.