CHELATING-AGENTS AS POTENTIAL ANTITUMORALS - 2-QUINOLYLHYDRAZONES ANDBIS-2-QUINOLYLHYDRAZONES .1.

Authors
SAVINI L MASSARELLI P CHIASSERINI L SEGA A PELLERANO C BARZI A NOCENTINI G
Citation
L. Savini et al., CHELATING-AGENTS AS POTENTIAL ANTITUMORALS - 2-QUINOLYLHYDRAZONES ANDBIS-2-QUINOLYLHYDRAZONES .1., European journal of medicinal chemistry, 30(7-8), 1995, pp. 547-552
Citations number
14
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
30
Issue
7-8
Year of publication
1995
Pages
547 - 552
Database
ISI
SICI code
0223-5234(1995)30:7-8<547:CAPA-2>2.0.ZU;2-4
Abstract
A number of pyruvic acid, methylpyruvate and pyruvic carboxaldehyde 2- quinolylhydrazones have been synthesized. Some bis-2-quinolylhydrazone s were also obtained during the reaction with pyruvic carboxaldehyde. All these compounds have been evaluated for cytotoxicity and most disp lay a significant in vitro activity against a variety of cell lines.