S. Guimaraes et A. Albinoteixeira, HYPERTENSION DUE TO CHRONIC BLOCKADE OF P-I-PURINOCEPTORS, Journal of autonomic pharmacology, 16(6), 1996, pp. 367-370
I Long-term treatment of rats with 1,3-dipropyl-8-sulphophenylxanthine
(DPSPX), a nonselective antagonist of adenosine receptors, causes a h
ypertensive state. 2 In DPSPX-hypertensive rats, prejunctional alpha(2
)-adrenoceptors become supersensitive to the selective alpha(2)-adreno
ceptor agonist UK-14,304, while postjunctional adrenoceptor-mediated r
esponses are not changed; furthermore, prejunctional beta-adrenoceptor
-mediated facilitation of noradrenaline release is also enhanced. 3 In
DPSPX-hypertensive rats, there are important morphological alteration
s of the small arteries, their lumina appearing strongly reduced and o
ccasionally occluded by proliferation of the intimal cells. 4 In DPSPX
-hypertensive rats, there is an increase in plasma renin, and captopri
l prevents not only the development of the hypertension but also the m
orphological changes in the arteries. 5 Other important changes occur
in DPSPX-hypertensive rats: an alteration of the adrenergic regulation
of the cardiac functions and an enhancement of perivascular neurotran
smission. 6 These results suggest that adenosine may play an important
role in the development of some kinds of human hypertension.